Wednesday, 10 January 2018

Major Causes Of Cushing's Syndrome You Should Avoid



Cushing's disease is a serious condition of an excess of the steroid hormone cortisol in the blood level caused by a pituitary tumor secreting adrenocorticotropic hormone (ACTH). ACTH is a hormone produced by the normal pituitary gland. ACTH stimulates the adrenal glands (located on top of the kidneys) to produce cortisol, commonly referred to as the stress hormone. Too much cortisol can produce some of the hallmark signs of Cushing syndrome a fatty hump between your shoulders, a rounded face, and pink or purple stretch marks on your skin. Cushing syndrome can also result in high blood pressure, bone loss and, on occasion, type 2 diabetes.
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Health Complications
Without treatment, complications of Cushing syndrome may include:

  • Bone loss (osteoporosis), which can result in unusual bone fractures, such as rib fractures and fractures of the bones in the feet. 
  • High blood pressure (hypertension)
  •  Loss of visual acuity (blurry vision), especially if the macroadenoma grows forward and compresses an optic nerve.
  • Loss of muscle mass and strength 
  • Generalized weakness and fatigue; wasting of muscles, most noticeably in the upper thighs. You may have difficulty getting up from a chair.
  •  Decreased fertility and/or sex drive
  • High blood pressure that is often difficult to treat
  • Diabetes mellitus, often severe 
  • Mood and behavior disorders; some patients have psychiatric disorders that require hospitalization
  •  Excess hair growth on the face, neck, chest, abdomen and thighs.
  •  Reduction of sex hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH).


Cushing's syndrome is very rare, affecting around 1 in 50,000 people. Anyone can get it, although it tends to affect adults aged from 20 to 50 years. Women are three times more likely to develop the syndrome than men.

Causes Of Cushing's Syndrome
Cushing's syndrome occurs when the body's tissues are exposed to high levels of cortisol for too long. Many people develop Cushing's syndrome because they take glucocorticoids-steroid hormones that are chemically similar to naturally produced cortisol such as prednisone for asthma, rheumatoid arthritis, lupus, and other inflammatory diseases. Glucocorticoids are also used to suppress the immune system after transplantation to keep the body from rejecting the new organ or tissue.

Other people develop Cushing's syndrome because their bodies produce too much cortisol. Normally, the production of cortisol follows a precise chain of events. First, the hypothalamus, a part of the brain about the size of a small sugar cube, sends corticotropin-releasing hormone (CRH) to the pituitary gland. CRH causes the pituitary to secrete adrenocorticotropin hormone (ACTH), which stimulates the adrenal glands. When the adrenals, which are located just above the kidneys, receive the ACTH, they respond by releasing cortisol into the bloodstream. Also the most common cause is related to.medications called glucocorticoids, also commonly known as steroids or prednisone.
These prescription steroids are used for conditions such as asthma, rheumatoid arthritis, lupus , or after an organ transplant . They are powerful anti-inflammatory medications. Taking too much, for too long, can lead to Cushing's syndrome.


Author: Richard Smith