Saturday, 6 January 2018

Alarming Causes Of Alzheimer's Disease, Note This!

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Alzheimer's disease is a progressive disease that destroys memory and other important mental functions. Alzheimer's worsens over time. Alzheimer's is a progressive disease, where dementia symptoms gradually worsen over a number of years. In its early stages, memory loss is mild, but with late age Alzheimer's, individuals lose the ability to carry on a conversation and respond to their environment. Alzheimer's is the sixth leading cause of death in the United States.
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Those with Alzheimer's live an average of eight years after their symptoms become noticeable to others, but survival can range from four to 20 years, depending on age and other health conditions. Alzheimer's disease is the most common type of dementia. The term "dementia" describes a loss of mental ability associated with gradual death of brain cells.

Causes Of Alzheimer's Disease

Like all types of dementia, Alzheimer's is caused by brain cell death. It is a neurodegenerative disease, which means there is progressive brain cell death that happens over a course of time. The total brain size shrinks with Alzheimer's - the tissue has progressively fewer nerve cells and connections.
While they cannot be seen or tested in the living brain affected by Alzheimer's disease, postmortem/autopsy will always show tiny inclusions in the nerve tissue, called plaques and tangles:
  • Plaques : These clumps of a protein called beta-amyloid may damage and destroy brain cells in several ways, including interfering with cell-to-cell communication. Although the ultimate cause of brain-cell death in Alzheimer's isn't known, the collection of beta-amyloid on the outside of brain cells is a prime suspect.
  •  Tangles : Brain cells depend on an internal support and transport system to carry nutrients and other essential materials throughout their long extensions. This system requires the normal structure and functioning of a protein called tau.
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Health Complications
Two abnormal structures called plaques and tangles are prime suspects in damaging and killing nerve cells.
◾Plaques are deposits of a protein fragment called beta-amyloid (BAY-tuh AM-uh-loyd) that build up in the spaces between nerve cells.
◾Tangles are twisted fibers of another protein called tau (rhymes with "wow") that build up inside cells.
Though most people develop some plaques and tangles as they age, those with Alzheimer's tend to develop far more. They also tend to develop them in a predictable pattern, beginning in areas important for memory before spreading to other regions.

Memory and language loss, impaired judgment, and other cognitive changes caused by Alzheimer's can complicate treatment for other health conditions. The principal side effects of ChEIs involve the gastrointestinal system and include nausea , vomiting, cramping, and diarrhea .

Usually these side effects can be controlled with change in size or timing of the dose or administering the medications with a small amount of food.



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Author: Richard Smith